A: Bacteria can become resistant to antibiotics through several ways. Some bacteria can БneutralizeБ an antibiotic by changing it in a way that makes it harmless. Others have learned how to pump an antibiotic back outside of the bacteria before it can do any harm. Some bacteria can change their outer structure so the antibiotic has no way to attach to the bacteria it is designed to kill. After being exposed to antibiotics, sometimes one of the bacteria can survive because it found a way to resist the antibiotic. If even one bacterium becomes resistant to antibiotics, it can then multiply and replace all the bacteria that were killed off. That means that exposure to antibiotics provides selective pressure making the surviving bacteria more likely to be resistant. Bacteria can also become resistant through mutation of their genetic material. The Food and Drug AdministrationБs (FDAБs) Center for Veterinary Medicine (CVM) produced a бexplaining how antimicrobial resistance both emerges and increases among bacteria.
Antibiotic resistance occurs when an antibiotic has lost its ability to effectively control or kill bacterial growth; in other words, the bacteria are resistant and continue to multiply in the presence of therapeutic levels of an antibiotic.
Antibiotic resistance is a natural phenomenon. When an antibiotic is used, bacteria that can resist that antibiotic have a greater chance of survival than those that are susceptible. Susceptible bacteria are killed or inhibited by an antibiotic, resulting in a for the survival of resistant strains of bacteria. Some resistance occurs without human action, as bacteria can produce and use antibiotics against other bacteria, leading to a low-level of natural selection for resistance to antibiotics. However, the current higher-levels of antibiotic-resistant bacteria are attributed to the overuse and abuse of antibiotics. In some countries and over the Internet, antibiotics can be purchased without a doctor s prescription. Patients sometimes take antibiotics unnecessarily, to treat viral illnesses like the common cold. Some bacteria are naturally resistant to certain types of antibiotics. However, bacteria may also become resistant in two ways: 1) by a genetic mutation or 2) by acquiring resistance from another bacterium. Mutations, rare spontaneous changes of the bacteria s genetic material, are thought to occur in about one in one million to one in ten million cells.
Different genetic mutations yield different types of resistance. Some mutations enable the bacteria to produce potent chemicals (enzymes) that inactivate antibiotics, while other mutations eliminate the cell target that the antibiotic attacks. Still others close up the entry ports that allow antibiotics into the cell, and others manufacture pumping mechanisms that export the antibiotic back outside so it never reaches its target. Bacteria can acquire antibiotic resistance genes from other bacteria in several ways. By undergoing a simple mating process called conjugation, bacteria can transfer genetic material, including genes encoding resistance to antibiotics (found on and ) from one bacterium to another. Viruses are another mechanism for passing resistance traits between bacteria. The resistance traits from one bacterium are packaged into the head portion of the virus. The virus then injects the resistance traits into any new bacteria it attacks. Bacteria also have the ability to acquire naked, free DNA from their environment.
Any bacteria that acquire resistance genes, whether by spontaneous mutation or genetic exchange with other bacteria, have the ability to resist one or more antibiotics. Because bacteria can collect multiple resistance traits over time, they can become resistant to many different families of antibiotics. Genetically, antibiotic resistance spreads through bacteria populations both vertically, when new generations inherit antibiotic resistance genes, and horizontally, when bacteria share or exchange sections of genetic material with other bacteria. Horizontal gene transfer can even occur between different bacterial species. Environmentally, antibiotic resistance spreads as bacteria themselves move from place to place; bacteria can travel via airplane, water and wind. People can pass the resistant bacteria to others; for example, by coughing or contact with unwashed hands. Yes, antibiotic resistance traits can be lost, but this reverse process occurs more slowly. If the that is applied by the presence of an antibiotic is removed, the bacterial population can potentially revert to a population of bacteria that responds to antibiotics.