why do tb patients have night sweats


organism. The bacteria themselves may also be releasing
fever-causing signals. In response to a while. Later, body temperature is returned to normal, and the extra heat is lost by sweating. triggering night sweats. Monocytes (a type of white blood cell) are a significant source of TNF- a. Monocytes leave the blood stream and become migratory macrophages, homing in on the tuberculosis-causing mycobacteria. Although the macrophages may be Pbacteria completely, in an immunocompetent person the macrophages and other cells are able to tissues. The excess TNF-a released during this immune response appears to be linked with the fevers, weakness, night sweats, necrosis, and progressive weight loss that are tuberculosis (Tramontana et al, 1995). It is possible to reduce TNF-a levels. For example, thalidomide suppresses TNF-a production characteristic symptoms and signs of tuberculosis. It is well tolerated Pby patients receiving anti-tuberculosis therapy, and is associated with accelerated weight (Tramontana et al, 1995). However, avoid reducing the persons natural immunity to tuberculosis.

For example, and rheumatoid arthritis, the patients have an tuberculosis (Keane et al, 2001). Infliximab reduces the apoptosis, and this may affect the integrity of the granulomatous tissue that clusters of tubercle bacteria. fever may not be perceived by a sleeping patient, who is more likely to be awakened by the discomfort of the subsequent sweating (Gobbi et al, 1 990). This may be the situation also with tuberculosis-linked night sweats. It is not clear why tuberculosis-induced fevers occur at night. PNormal human body temperature displays a circadian rhythm, and Ppredawn hours at 36. 1` C before rising to 37. 4` C or higher in the afternoon (Young, 1988; Boulant, 1991, Dinarello and Bunn, 1997), so the fever/sweating events are probably linked with this daily cycle. There are three phases to fever. In the initiation phase, cutaneous vasoconstriction promotes heat retention and shivering generates additional heat. When the new (elevated) set point is reached, heat stops.

With lowering of the set point to normal, c environment in the form of sweating (Young, 1988; Boulant, 1991, Dinarello and Bunn, 1997; Cleary, 1998). Night sweating can arise from harmless situations or serious disease. If your bedroom is unusually hot or you are using too many bedclothes, you may begin to sweat during – and this is normal. In order to distinguish night sweats that arise from medical causes from those that occur because one s surroundings are too warm, doctors generally refer to true night sweats as severe hot flashes occurring at night that can drench sleepwear and sheets, and that are not related to an overheated environment. It is important to note that flushing (a warmth and redness of the face or trunk) may also be hard to distinguish from true night sweats. There are many different causes of night sweats. Some of the known conditions that can cause night sweats include: : Night sweats are an early symptom of some cancers. The most common type of associated with night sweats is. also may cause night sweats.

However, people who have an undiagnosed frequently have other symptoms as well, such as unexplained and fevers. : Sometimes can cause sweating. People who are taking insulin or oral anti-diabetic medications may experience hypoglycemia at night that is accompanied by sweating. Hormone disorders: Sweating or flushing can be seen with several hormone disorders, including pheochromocytoma, carcinoid syndrome, and. Neurologic conditions: Uncommonly, neurologic conditions including autonomic dysreflexia, post-traumatic syringomyelia, and may cause increased sweating and possibly lead to night sweats. Idiopathic : Idiopathic hyperhidrosis is a condition in which the body chronically produces too much sweat without any identifiable medical cause. Infections: Classically, is the infection most notoriously associated with night sweats. However, such as those that cause endocarditis (inflammation of the ), osteomyelitis (inflammation within the bones), and abscesses all may result in night sweats. Night sweats are also a symptom of.

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